Nadeem et al., 2019)
[DOI] [PubMed] [Google Scholar] 131.Oakley A.J., Lo Bello M., Battistoni A., Ricci G., Rossjohn J., Villar H.O., Parker M.W
The breakdown of hemoglobin releases a substantial quantity of iron ions, leading to significant reduction in cell viability, superoxide dismutase and glutathione levels, increased generation of reactive oxygen species, lipid peroxidation and malondialdehyde levels, as well as upregulation in the expression of ferroptosis-related proteins that induce mitochondrial ultrastructural changes
The nucleophilic attack of GSH at the selenium center is expected to favor due to noncovalent interactions between the selenium and one of the carbonyl oxygen
Stadlbauer, V
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