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Discovery of 2-[3,5-Dichloro-4-[5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196], a highly selective thyroid hormone receptor agonist in clinical trials for the treatment of dyslipidemia

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