GLP-1 drugs are not just gut hormones, they cross the blood-brain barrier and bind to receptors in the mesolimbic system, which modulates reward signalling
For daily GLP-1 medications, taking them in the evening might help you sleep through peak nausea periods, though this effect may be limited for weekly injections due to their long half-life
Add liquid slowly during reconstitution Aim down the vial wall, not directly onto lyophilized powder
Patients with a history of sensitive GI systems may do better starting with semaglutide and escalating if needed
However, they can induce adverse effects, and there is a lack of evidence to support their ability to promote healthy aging and life expectancy [11,12,197]
Inject diluent down the inside wall of the vial do not aim directly at the lyophilised powder