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Dihexa has been studied in preclinical models of cognitive function, Alzheimers-like neurodegeneration, and dendritic spine formation, where it has been reported to promote functional synaptogenesis with high potency in neurotrophic assays

^ Determination of blood total, reduced, and oxidized glutathione in pediatric subjects

A phase II trial focusing on individuals with overweight or obesity, coupled with hypertension or dyslipidemia but without T2D, found that cagrilintide (2.4 mg) alongside diet and exercise, led to a 10% body weight reduction compared to 3% with placebo over 26 weeks [99]

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Singly-housed rodents may have increased adiposity 101 and, moreover, singly-housed mice in standard caging can engage in coprophagy of their own feces that may impact their cecal microbiome 102

doi: 10.1016/j.jep.2004.12.022 140