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Weisbrodt, N

It influences upstream pathways but is not a pharmacological therapy

Among the malignancies found in the genitourinary (GU) system, renal cell carcinoma (RCC) and urothelial carcinoma (UC) benefit most from immune-checkpoint inhibitors (ICIs) alone or in combination with other ICIs or tyrosine kinase inhibitors (TKIs)

With four compounds and twelve possible interaction pairs, troubleshooting is substantially more complex than with a three-compound protocol

Signal mining and statistical analysis Disproportionality analysis serves as a crucial tool for pharmacovigilance to identify potential drug-event safety signals 23

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