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This was however associated with blunted responses to pharmacological GLP-1RAs in vivo

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Cotsiranib is a siRNA therapy developed by Sirnaomics that uses the PNP delivery platform, containing two active siRNAs targeting TGF1 and cytochrome C oxidase subunit 2 mRNA

Ongoing studies into non-invasive delivery methods could offer more patient-friendly options in the future

( f ) Schematic diagram of the ex vivo two-photon slice imaging of cADDis fluorescence from AP Glp1r slices