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doi: 10.1007/s00404-016-4136-4 67 SanchezAMPapaleoECortiLSantambrogioPLeviSViganPet al

By this direct route, very high concentrations of the drug can be achieved in the CSF and adjacent brain tissue, especially around the ventricles and spinal canal

Lidocaine can also increase the expression of ACSL4 by directly knocking down miR-424-5p to promote lipid peroxidation in ovarian cancer cells and increase their sensitivity to the ferroptosis activators erastin and RSL3 (88)