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Insulin receptors are extensively distributed throughout but are particularly abundant in regions such as the olfactory bulb, cerebral cortex, hippocampus, hypothalamus, and cerebellumareas integral to learning, memory, and emotional regulation [96]

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But Mounjaro (tirzepatide) consistently shows the strongest results

Together, they target both appetite regulation and metabolic substrate utilization

The amount of insulin delivered by insulin pump or insulin injected may not be sufficient

The comparator groups differed among studies, with some employing placebo controls (e.g., PIONEER-6, Gerstein 2019), others using active comparators such as sitagliptin, glimepiride, DPP-4 inhibitors, or SGLT2 inhibitors, and some utilizing standard care or intensive lifestyle interventions as the control