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Drugs that have boxed warnings can be effective treatment options

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MAS825, an IL-1 blocker that also blocks IL-18, another cytokine, has previously been studied for COVID-19 infections, and is now in a phase II trial investigating its efficacy for HS

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For peptides with long half-lives (e.g., growth hormone secretagogues like MK-677 with a 24-hour half-life), staggering provides limited benefit in those cases, reduce peptide dose to 5070% of standalone effective dose instead

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