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The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome

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Important questions include Whether long term use is anticipated What is known about discontinuation How maintenance is approached if therapy changes Follow up analyses from randomized controlled trials show that discontinuing GLP 1 therapy is commonly associated with a return toward baseline weight or metabolic set point

The PIONEER trials for oral semaglutide and emerging sublingual data support modest but measurable benefit, though typically below injection-level results