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A newborn with male phallus or hypospadias, atypical external genitalia and bilateral non-palpable gonads is potentially a genetic female (46,XX) with congenital adrenal hyperplasia due to 21-hydroxylase deficiency or another rare defect of adrenal and gonadal steroidogenesis (11 beta-hydroxylase deficiency, steroidogenic acute regulatory protein (StAR) or cholesterol side-chain cleavage enzyme defect)

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The high intracellular calcium concentration enhances a quick inhibition (equation 4), thus reducing the fraction of active receptors below the critical threshold, 2), in which case, the pulse is terminated by exponential removal of the calcium (equation 3)