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Regulatory frameworks that allow robust real-world evidence to substitute for certain pre-approval clinical requirements, while maintaining post-approval pharmacovigilance standards, would reduce pre-approval cost while actually enhancing the breadth of safety monitoring across diverse patient populations

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So while I wouldnt wait in between an AHA and L-ascorbic acid, for example, Id do so with a higher-pH vitamin C derivative, such as: Ascorbyl glucoside: pH 5.0-7.0 Ascorbyl tetraisopalmitate: pH 4.0-6.0 Ethyl ascorbic acid: pH 4.0-5.5 Magnesium ascorbyl phosphate: pH 6.0-7.0 Sodium ascorbyl phosphate: pH 6.0-7.0 The same goes for vitamin C formulas that are anhydrous (water-free), which dont have a pH level at all