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PLGA is a hydrophobic polymer, which is more suited to encapsulate hydrophobic rather than hydrophilic agents via two general methods 4 : (1) Nanoprecipitation, in which PLGA and agents to be encapsulated are dissolved in a good solvent and then co-precipitate into nanoparticles upon addition into a non-solvent for both

Carnitine palmitoyl transferase 2 (CPT-2) deficiency: involves the ineffective conversion of long-chain to acyl-CoAs

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This leads to reduced caloric intake, and ultimately weight loss as a result

The integrated stress response