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In addition, HIF-2 induces the expression of Gln transporter SLC7A5 and activation of mTORC1, leading to cell proliferation and tumor growth [88]

In a phase 2B study of lanifibranor, the percentage of patients who achieved at least a two-point reduction in the SAF-A score without fibrosis progression was significantly higher among those receiving the 1,200-mg dose compared to placebo (1,200-mg dose vs

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