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Development of cagrilintide, a long acting amylin analogue

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28 Further, it transformed into water in the presence of catalytic enzymes like glutathione peroxidases (GPx) and peroxiredoxins

Non-glutathione disulfide substrates that employ monothiol mechanism (iii) should not be trapped as Grx(SSR) intermediates, which might explain the rather small number of verified non-glutathione disulfide substrates of glutaredoxins to date

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Nrf2 also counteracts sorafenib-induced ferroptosis by upregulating the iron and reactive oxygen metabolism-related genes HO-1 via the P62-Keap1-Nrf2 pathway (Sun et al., 2016b)