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It is a GH secretagogue and an agonist, meaning it may bind to specific cell receptors and cause a physiological reaction

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10.2174/13816128113190990411 126 SikiricP.SeiwerthS.RucmanR.TurkovicB.RokotovD

James SJ, Melnyk S, Fuchs G, Reid T, Jernigan S, Pavliv O, Hubanks A, Gaylor DW: Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism

This study discussed the changes of metformin on 4EBP1, S6K1, and mTOR in colon cancer cells from the mRNA level and protein level, and confirmed that metformin can further promote cell apoptosis by inhibiting the activity of the mTOR signaling pathway and inhibiting the levels of 4EBP1 and S6K1, showing an obvious dose-dependent effect (58)

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