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It took 20 years for the oral contraceptive pills side-effects to be brought to public awareness

Fat loss comes from the caloric deficit created by reduced food intake

NICE guidance (CG189) recommends drug treatment only as part of an overall plan for managing obesity in adults who have not reached their target weight loss or maintained weight loss with lifestyle changes alone

Nausea is the most frequently reported adverse effect, potentially affecting thirty to forty percent of patients at some point during treatment, though the intensity typically diminishes over time as tolerance develops

L., Garca-Domnguez J., Arias J

This protocol approaches the upper bounds of documented use and should not be exceeded without specific medical supervision