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Acetyl-L-carnitine can be taken alone for peripheral neuropathy, in combination with bio-active R-lipoic acid, or together with other therapies

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The conjugation is a two-step process which involves a conjugation of the NHS-activated ester of the bifunctional linker, SMCC, to trastuzumab followed by the reaction of the sulfhydryl from DM1 with the maleimide

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