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Various databases (Medline/PubMed, Scopus, and Web of Science) were systematically searched for relevant English language articles published up to April 2023

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Treatment typically begins with a low dose and is gradually increased at weekly or biweekly intervals

outcomes depend on baseline BMI, diet quality, physical activity, and metabolic response

Furthermore, recent findings reveal that alterations in BBB and its transporters affect the entry of therapeutic drugs designed to treat neurodegenerative diseases (Zhang, 2025)

The article states that GLP-1 therapy after cholecystectomy is not contraindicated, but that it warrants closer monitoring than in patients whose gallbladder is intact