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This study utilized a CASSCF approach to demonstrate that while all forms of vitamin B12 interact with glutathione, NADPH, FMN, and FAD by breaking Co-C or Co-O bonds and facilitating electron transfer, only glutathione effectively converts cyanocobalamin into a biologically active form, aligning with clinical observations

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In particular, heated products for diabetics made from fructose or heat-treated foods, sweetened with corn syrup or high-fructose corn syrup, may contain lower amounts of folates due to glycation reaction 556

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PMID 2172707