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However, GLP-1R is widely expressed in various central areas as hypothalamic nuclei orchestrating the release of GnRH and LH, and more recently was also identified in testicular cells [139]

To rule out the possibility that lean mass loss following BW reduction could have affected creatinine-based eGFR measurement, the muscle mass-independent endogenous filtration marker cystatin C was used to confirm the renal favorable effects attributed to tirzepatide [52]

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