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PMID 25189324

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It is considered investigational, which is precisely why medical supervision is essential before considering it

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Signs of a severe allergic reaction (anaphylaxis) include: Skin rash, hives, or severe itching Swelling of the face, lips, tongue, or throat Difficulty breathing or wheezing A rapid heartbeat or a sudden drop in blood pressure If you ever develop swelling of the face or throat, trouble breathing, or other signs of a severe reaction after any injection, treat it as an emergency and call 911

Changing the base semaglutide dose may make it less effective for weight loss