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When G6PD is inhibited in murine cells both in vivo using 6-AN or knockdown, or in vitro using 6-AN or a novel selective small molecule inhibitor of G6PD (G6PDi-1), efferocytosis of apoptotic cells is significantly diminished 107,108,109

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Neuronal cell exposure to these ROS, which include nitric oxide, superoxide ions and hydroxyl radicals, can result in oxidative deoxyribonucleic acid (DNA) damage [1114]