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Those most at risk include vegans and vegetarians, people with digestive conditions such as Crohn's disease, coeliac disease or IBS, those taking long-term metformin or proton pump inhibitors, older adults whose ability to absorb B12 through the gut declines naturally with age, those with pernicious anaemia, and anyone with a history of chronic alcohol use

Vitamin B12: Health professional fact sheet

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The compound's exceptional selectivity for NNMT, combined with its favorable safety profile and membrane permeability characteristics, positions it as an invaluable resource for researchers investigating fundamental questions in metabolism, aging, and cellular energetics