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High weight loss (15 to 17% body weight in trials)

What is Vitamin B12 and Why Do You Need It

The proposed mechanism for hyperhomocysteinaemia on inducing endothelial dysfunction and thus atherosclerosis includes homocysteine-induced endoplasmic reticulum stress, oxidative stress, and proinflammatory response.48 Animal models of hyperhomocysteinaemia have confirmed the causal relationship between hyperhomocysteinaemia and the development of endothelial dysfunction and accelerated atherosclerosis.48 Although meta-analyses have shown reduction of cardiovascular risk with reduction of homocysteine levels,46 47 vitamin supplementation (with vitamin B 6 , vitamin B 12 , and folic acid) to lower homocysteine in the body may not be transformed into clinically beneficial vascular outcomes

Contributor, and Hope Ricciotti, MD, Editor at Large, Harvard Women's Health Watch Q

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222

It takes about three weeks before you will notice any improvement in treated areas