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Possible side effects include headaches, nausea, injection site reactions, water retention, and hormonal imbalances

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In 2017 the FA approved it for that purpose

The body stops listening to the hormone signal as strongly

Greene, K

In recent years, the gut-brain axis has been increasingly considered a promising topic for the study of CNS-related diseases because the gut microbiota and gut hormones have been shown to interact with other organs including the brain (Knight et al., 2017), although the mechanisms involved in gut homeostasis and brain function are as yet uncharacterized (Neufeld and Foster, 2009)