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SLE can affect nearly every organ system, manifesting in complications such as lupus nephritis (kidneys), neuropsychiatric disease (central nervous system), cutaneous lupus (skin), lymphadenopathy (lymphatic system), and various cardiovascular conditions (283, 284)

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The local administration of liposome-encapsulated catalase and superoxide dismutase has been reported to reduce periodontal inflammation in beagles [138]