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Acetylation and level of mitochondrial transcription factor A in several organs of young and old rats

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10.1016/j.molcel.2022.03.022 38

We also summarize newly proposed mechanisms associated with hepatoprotection and tumor suppression, such as attenuation of hepatocellular stress through inhibition of the NEDD9/FAK/AKT cascade and a potential role in cell-cycle regulation via the HDAC/p21 axisalthough the latter remains to be validated in MASLD-specific models

However, competitions such as Critical Assessment of Functional Annotation [21] have not yet found a solution for de novo function prediction from sequence

While uncommon, patients with known health issues need to discuss risks with their doctor and undergo monitoring before and during treatment