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For other autoimmune conditions, no specific contraindications have been identified beyond the general GLP-1 precautions, but individual risk-benefit assessment with a healthcare provider is essential

Eur J Gastroenterol Hepatol 1993, 5, suppl 3, 117-123

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Peroxynitrite is highly toxic to neurons and causes hyper-excitability of the central nervous system, a process known as "kindling." This leads to autonomic nervous system dysfunction (dysautonomia), sensory overload, and severe cognitive deficits

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Lack of glutathione peroxidase-1 exacerbates a beta-mediated neurotoxicity in cortical neurons