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Furthermore, this effect of GIPRA depends on GIPR expression in AP neurons [30]

(1) Controlled-Release PHEN/TPM in Severely Obese Adults (EQUIP) trial (obesity without comorbidities), (2) Controlled-Release Phentermine plus Topiramate Combination in Overweight and Obese Adults (CONQUER) trial (obesity with comorbidities), and (3) SEQUEL (2-year extension of CONQUER), were comprised of 7% of older adult participants across the trials, although the upper age limit was 70 [111,112,113]

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Do not use GLP-1 + GIP treatments if: Warnings and Precautions: Pregnancy and Reproductive Health: GLP-1 + GIP medications may cause harm to a fetus and should not be used during pregnancy or by individuals planning to become pregnant

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The reason is that not all doctors understand the benefits that they can get from it