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[PubMed: 4812617] 411

DV-P was supported by the NSF Graduate Research Fellowship Program (DGE 2139839)

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The 10 mg dose of tirzepatide showed greater weight reduction versus semaglutide 1 mg by -1.8 mmHg (-3.4 to -0.1) while the 15 mg dose of tirzepatide reduced an additional -3 mmHg (-4.6 to -1.3) compared to semaglutide [65]

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GLP-1 receptor agonists work through several mechanisms to promote weight loss: Appetite suppression : Semaglutide acts on receptors in the brain's appetite centres, particularly the hypothalamus, reducing feelings of hunger and increasing satiety after meals