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However, one study into the use of one of these medications, Mounjaro, found that approximately 500,000 people in the UK have used the drug privately for weight loss since 2023

Clinical researchers had seen incremental improvements with each new medication class, but Retatrutide represented something different altogether

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The injectable versus oral peptide comparison is also relevant here, because some researchers transitioning from oral semaglutide may have different GLP-1 receptor adaptation profiles than those coming from injectable formulations

Illustration by Donnisa Edmonds