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doi:10.1056/NEJMoa2032183 10

TMX-intoxicated rats had significantly higher expression levels of cleaved caspase-3 ( F (3, 16) = 105.83

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Based on these studies, elevated C2, C3-DC, C4, or C5 imply impaired metabolism of BCAAs and/or metabolic inflexibility, therefore, supporting their use as potential early biomarkers of the onset of PRIS that could be incorporating into a therapeutic monitoring strategy for propofol [97,98,99,131]