Initially, these medications were developed for the treatment of type 2 diabetes mellitus, but GLP-1 RA drugs have demonstrated remarkable outcomes in clinical settings
Diabetic neuropathy: A narrative review of risk factors, classification, screening and current pathogenic treatment options
In human iPSC-derived neurons, EHMT1 deficiency leads to upregulation of NRSF/REST target genes, which results in elevated expression of the human pro-neural transcription factors MASH1 and NGN2 (Alsaqati et al., 2022)
Advanced glycation end products and the kidney
PEGylating or fusing peptide with albumin/Fc domain are also feasible and even the DPP-4 would be resisted by steric hindrance if the latter method is taken
However, high SUOX expression has also been associated with disease recurrence after surgery in prostate and lung cancer (402, 403)