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There are no biosimilar alternatives, which are often less expensive

J Orthop Res 24:982989 Liu C, Aschbacher-Smith L, Barthelery N, Dyment N, Butler D, Wylie C (2011) What we should know before using tissue engineering techniques to repair injured tendons: a developmental biology perspective

ESCs are derived from epiblast of the blastocyst from which many tissues of embryo arise, whereas ASCs are localized in adult organs [Table 2] where these cells function to replace damaged cells during tissue regeneration.[26,27] SCs are further classified into four types based on their transdifferentiation potential which include totipotent, pluripotent, multipotent and unipotent SC.[24] ESCs are known to have totipotent and pluripotent in nature and have the ability to differentiate into cells of three germ layers endoderm, mesoderm and ectoderm.[28] ASC is multipotent and can give rise to differentiated cells of anyone germ layer.[29] Unipotent SCs arise from multipotent cells and are dedicated to differentiate into specific type of tissue, for example, precursors for cardiomyocytes present in human heart or satellite cells characteristic for skeletal muscles are dedicated to differentiate into specific tissue.[30] Table 2

Documented success stories, including cases of significant weight loss over several months, demonstrate the potential effectiveness of this treatment approach

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