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The better option depends on BMI, weight-related health conditions, appetite patterns, insulin sensitivity, medical history, medication tolerance and provider recommendation

Despite significant advances in MASLD diagnosis [31, 32], histological assessment through a liver biopsy remains the gold standard for diagnosing, staging, and prognosing MASLD/MASH, as well as for accurately monitoring fibrosis progression [33]

Importantly, despite modest heart rate increases, cardiovascular outcomes trials have not demonstrated increased cardiovascular risk

However, the clinical efficacy of probiotics in CD patients remains unclear, with inconsistent results from multiple clinical trials, and they cannot yet be widely recommended [413, 416]

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Weight Loss Outcomes Patients initiated semaglutide 64.7 47.6 months (mean SD) after bariatric metabolic surgery at a BMI of 38.3 6.4 kg (mean SD)