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Usually, cutaneous melanoma begins in the epidermis (the top layer of skin) and can become invasive from there

It has been demonstrated that lipid peroxidation and subsequent ferroptosis following abnormal ALOX gene expression in keratinocytes are involved in the normal epidermal differentiation and maintenance of skin homeostasis, and might also engage in the development of skin squamous cell carcinoma (Egolf et al., 2021)

On human fibroblasts, after AGEs bind to the receptors, they increase the production of ROS and NF-kB [25]

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all those fruits are naturally rich in ascorbic acid, which may protect folates against pressure and heat degradation 365,477,479