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For those who are considering GLP-1s, it helps to understand what is FDA-approved today, what the results look like on average, and what tradeoffs come with pills versus injections

Since the borders of our cells are made of fats, things that can pass through fats (called fat-soluble ) can easily pass through the cell membranes

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Microenvironment-sensitive designs, including hypoxia-responsive linkers, MMP-cleavable coatings, and tumor-penetrating peptides, facilitate deeper payload diffusion into poorly perfused tumor regions

Lopez-Martinez MI, Miguel M, Garces-Rimon M

42 The effects of GLP-1 RAs in HFrEF have been studied in several small trials