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According to another analysis [34], the published results, as a rule, show an improvement in some brain parameters (for example, hippocampal connectivity, glucose metabolism in the brain, hippocampal activation according to functional magnetic resonance imaging), but could not demonstrate a strong correlation with cognitive indicators

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The cagrilintide and semaglutide combination shows enhanced weight loss compared to either drug alone

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54 In another phase 2 trial done to evaluate the efficacy of orforglipron in adults with obesity without diabetes, it was found to lead to significant weight reduction compared to placebo