GLP-1RAs are a relatively new class of injectables that are effective at reducing HbA 1c , have a low risk of hypoglycaemia when given as monotherapy or in the absence of sulphonylureas (SU) or insulin, and have the potential for weight losskey considerations when treating a typical obese patient with T2DM [4]
For millions of people who have struggled with weight loss despite genuine effort, this medication represents a fundamentally different approach: one that addresses the biological mechanisms driving weight gain rather than relying solely on willpower
The overall cohort was propensity-matched 1:5 to eligible patients who initiated a GLP-1 after their index event and those who did not
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This is especially true for some women with polyendocrine metabolic ovarian syndrome (PMOS), a condition marked by irregular periods or absent ovulation
333,334 However, in patients with T2DM, correcting hyperglycemia with insulin therapy has a limited impact on DPN
