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If itching is severe or accompanied by hives away from the injection site, seek medical attention, this could indicate a systemic allergic reaction

However, their frequency and intensity can vary

The architecture of a characteristic TME consists of the extracellular matrix (ECM) elements, fibroblasts, myofibroblasts, adipose cells, immune and inflammatory cells, endothelial cells, and pericytes, supplemented with secreted cytokines, chemokines and enzymes (Yang et al., 2011

An increased GSH status may help mitigate oxidative stress induced by HFD intake

Take a deep breath and insert the needle at a 90-degree angle in one confident motion

For quantitative analysis, stained sections were imaged under a polarized light microscope (Leica, Germany), and the collagen-positive area was quantified using ImageJ software