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Current cancer treatment strategies have become increasingly refined, with emerging approaches such as targeted therapy and immunotherapy increasingly integrated into clinical practice

Two patterns appear in the literature

Due to decreased cardiolipin metabolism, melanocytes from vitiligo patients have low energy production from glycolytic phosphorylation (due to defects in complex 1), resulting in low ATP production and high mitochondrial ROS production (Figure 2

This microenvironment is of extreme importance due to its role not only as a structural, modifiable, and flexible scaffold for cells but also as a provider of a range of biochemical and biophysical signals that collectively regulate cell behaviors such as spreading, proliferation, migration, differentiation, and apoptosis [87]

doi: 10.1016/j.bbagen.2012.09.008 74 LuJ.HolmgrenA