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The most commonly reported adverse events in the Phase 2 trial were gastrointestinal in nature including nausea, vomiting, diarrhoea, and constipation consistent with the GLP-1 receptor agonist class

Boknik P, Grote-Wessels S, Barteska G, Jiang M, Mller FU, Schmitz W, Neumann J, Birnbaumer L (2009) Genetic disruption of G proteins, G(i2)alpha or G(o)alpha, does not abolish inotropic and chronotropic effects of stimulating muscarinic cholinoceptors in atrium

Spreading protein across multiple smaller feedings throughout the day is significantly more effective

That single regulatory point has practical consequences

Two additional endpoints are worth noting