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Tonolo F, Folda A, Cesaro L et al (2019) Milk-derived bioactive peptides exhibit antioxidant activity through the Keap1-Nrf2 signaling pathway

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The closest human evidence in its drug class is Athira Pharma's fosgonimeton (ATH-1017), a structurally distinct molecule in the same HGF/c-Met program whose Phase 2/3 LIFT-AD Alzheimer's trial failed its primary endpoint in September 2024 (GST 0.08, P=.70)

These complementary approaches, combined with advanced co-culture systems that partially reconstruct testicular cellular interactions, currently represent the most reliable in vitro tools for EED reproductive toxicity research

According to Hassel et al., the accumulation of -glutamate semialdehyde (GSA) and P5C in the brain may contribute to the development of mental retardation in patients [20]