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3 Mechanisms by which gut microbiota dysbiosis promotes metabolic abnormalities in PCOS Gut microbiota dysbiosis may influence the metabolic homeostasis of patients with PCOS through various mechanisms, potentially promoting the onset of metabolic conditions such as insulin resistance, glucose metabolic disorders, and disturbances in lipid metabolism (see Figure 1 )

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8 Health Issues Associated with ADE ADE has been observed to potentially escalate multiple viral infections, such as in the case of respiratory syncytial virus (RSV) 53,141 and measles 142,143

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