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The connection between glutamate- and cysteine-induced cytotoxicity and cancer cell death may have initially inspired the concept of ferroptosis [20, 21], and research on oxidative stress-induced non-apoptotic cell death in neurons was reported in 2001 [22]

Membrane isolation and solubilization (for fluorescent protein-based FSEC-TS assay) Membranes were isolated as follows

Depletion of endogenous GSH sensitizes cells to cuproptosis, whereas GSH supplementation mitigates copper-induced proteotoxic stress 164,168