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High NNMT expression is closely associated with glucose dysregulation: excessive NNMT activation disrupts nicotinamide metabolism, lowers NAD+ levels, impairs insulin signaling, reduces cellular glucose uptake and utilization, and promotes hyperglycemia and insulin resistance

The cited evidence used rodents and cell cultures dosed with BPC-157, not the arginate salt

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Systemic bioavailability with standard oral forms is very low Oral vs