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The agonist exclusively activates GLP-1R , driving glucose-dependent insulin secretion, delayed gastric emptying, and central satiety signaling (hypothalamic arcuate nucleus)

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Gastrointestinal: Mild transient diarrhea

And 20 years later, they are now being marketed specifically for weight loss and diabetics, but also just overweight, obese people

Melanin is also responsible for overall skin color and the darkening seen with a sun tan