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At 72 weeks, tirzepatide resulted in 20.2% average weight loss compared to 13.7% with semaglutide

Semaglutide directly activates GLP-1 receptors in the brain and gut, reducing hunger and slowing gastric emptyingmechanisms that directly lower calorie intake

However, too much vitamin B6 (pyridoxine), especially more than 50 mg daily, can actually cause nerve damage

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But theres no data showing how well it works in humans, and the long-term safety of this peptide in humans is simply unknown

However, realistic expectations remain essential for long-term satisfaction