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10.1021/bi00793a015 364 LehrerS
Early impairment of NGF/TrkA signaling in AD can lead to reduced synaptic vesicle secretion and decreased presynaptic protein expression, resulting in presynaptic functional impairment of cholinergic primary neurons [88]
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Managing it means eating low-histamine, fresh foods, going gluten free, avoiding DAO-blocking meds and alcohol, and supporting DAO with nutrients like vitamin C, B6, and copper
IGF-1/PI3K/Akt signaling reduces during denervation-, unloading-, and joint immobilization-induced muscle atrophy, whereas IGF-1/PI3K/Akt signaling seems unaltered during aging-associated muscle atrophy